The Science Behind PureSperm™

15 Jan 2026 | News, Tips & Tricks

PureSperm™ owes its performance to a precisely engineered colloidal silica system. The silica particles are synthetically produced and undergo silanization, a chemical process that stabilizes their surface and prevents aggregation. This creates a uniform, stable dispersion that is essential for consistent, high-quality results.

The colloidal solution is further refined with sodium, potassium, and calcium salts, carefully balanced to mimic the physiological environment of human spermatozoa. Osmolality and pH are adjusted to fall between those of liquefied semen and fertilization media, providing an extracellular environment that supports optimal sperm separation and purification.

PureSperm™ is the practical expression of this advanced chemistry: a sterile colloidal silica suspension in an isotonic salt solution, specifically optimized for density gradient preparation in Assisted Reproduction Technologies (ART). It efficiently isolates normal, motile sperm from lymphocytes, epithelial cells, abnormal, immature, or senescent sperm, cell debris, bacteria, and seminal plasma.

By combining advanced colloidal chemistry with physiological precision, PureSperm™ provides a reliable medium that enhances the efficiency and reproducibility of sperm preparation. Its performance advantages include:

· Increases sperm survival time.
· Removes sources of ROS.
· Removes bacteria.
· Removes sperm with abnormal DNA.
· Improves cryo-survival.
· Improves yield and recovery compared to swim-up techniques.

PureSperm™ provides laboratories with a robust, clinically proven solution that elevates the quality of sperm preparation — and ultimately supports improved outcomes in ART procedures.

Swim-up versus density gradients for sperm preparation in infertile couples undergoing intrauterine insemination: a randomized clinical trial
Tuyen N.D. Duong et al.

 

Other news from the Nidacon world

Microbiome and Infertility

We recently had the pleasure of having Hana Shabana, present the EMT study that will be conducted at Karolinska and several other sites across Sweden. The session focused on the value of the microbiome and how to interpret it from a biological perspective. If you...

Ready-to-use simplicity with glass tube advantages

With SpeediKit, sperm separation becomes simple. The medium is pre-filled in glass centrifuge tubes, so you can begin immediately, no preparation or manual layering required. Why glass matters The SpeediKit tubes are made of borosilicate glass, engineered for...

How to assess sperm vitality with Sperm VitalStain

We recently received an excellent question: How do you assess sperm vitality with Sperm VitalStain in viscous sperm samples? First, we recommend diluting the sample using PureSperm Buffer when preparing a smear from raw ejaculate. This makes the procedure easier and...

Simple and sustainable transport

All our products can be transported without a cold chain and stored at room temperature until opening. This simplifies logistics and provides a more environmentally friendly alternative to temperature controlled transport. To ensure reliability, we have conducted...

Closed for Easter

Nidacon will be closed for Easter from April 3rd to April 7th. To ensure timely delivery, please place your orders no later than April 2nd. We will be back in the office on April 7th and will process all incoming orders soon as possible.        ...

ESHRE 2026

We’re excited to share that Nidacon will be attending ESHRE 2026 in London! We look forward to meeting our partners, friends, and colleagues from around the world. Make sure to stop by Booth B21 — we’d love to see you there!

Enhance semen preparation with PureSperm™ Buffer

Achieving consistent, high-quality sperm preparation results depend heavily on maintaining optimal sample conditions. Two common challenges—rising osmolality over time and high semen viscosity—can compromise sperm function and reduce recovery rates. PureSperm™ Buffer...

Fertility 2026

Nidacon is delighted to share that we will be showcasing at Fertility 2026, taking place January 7th–10th in Edinburgh, together with our valued partner Hunter Scientific. We warmly look forward to meeting colleagues, collaborators, and friends from across the...

How Sperm CryoProtec Protects Sperm During Freezing

As the holiday season approaches and many of us are longing for colder winter weather, it feels fitting to highlight how Sperm CryoProtec protects sperm during the freezing and thawing process. The role of glucose in Sperm CryoProtec Osmotic balance: Glucose acts as...